Development and Characterization of Microparticles with Actinidia arguta Leaves Extract by Spray-Drying: A New Mind-Set Regarding Healthy Compounds for Oral Mucositis

Actinidia arguta leaves have gained notoriety over the past years due to their rich bioactive composition with human pro-healthy effects, particularly in relation antioxidants. Nevertheless, antioxidants are well known for chemical instability, making it necessary develop suitable delivery systems, such as microparticles, provide protection and ensure a controlled release. The aim of this work was produce polymeric particles A. extract by spray-drying that may improve oral mucositis condition. Microparticles were characterized size, shape, antioxidant/antiradical activities, swelling capacity, moisture content, effect on cells (TR146 HSC-3) viability, assess potential application results attested microparticles’ spherical morphology production yields 41.43% 36.40%, respectively, empty microparticles. microparticles obtained highest phenolic content (19.29 mg GAE/g) activities (FRAP = 81.72 µmol FSE/g; DPPH 4.90 TE/g), being perceived an increase capacity. No differences observed between loaded through FTIR analysis. Furthermore, exposure HSC-3 TR146 did not lead viability decrease, attesting safety administration. Overall, these highlight significant applications pharmaceutical nutraceutical industries.